Hezkue®

What is Hezkue?

Hezkue® is an oromucosal spray suspension containing sildenafil, a PDE5 inhibitor used to treat erectile dysfunction in adult men. It works by relaxing the blood vessels in the penis, improving blood flow when sexually stimulated.

How does Hezkue work?

Hezkue increases blood flow into the penis during sexual arousal by inhibiting the PDE5 enzyme, allowing better erections. It only works when sexually stimulated, and does not increase libido.

How do I take Hezkue correctly?

• Standard dose: 50 mg = 4 pumps (2 ml).
• Adjustments may be made to 25 mg (2 pumps) or 100 mg (8 pumps) depending on response.
• Take about 1 hour before sexual activity.
• Do not exceed one dose per day.
• Shake vigorously for 20 seconds before each use.
• Prime the pump three times before each dose (discard priming sprays).
• Spray onto the tongue and swallow immediately.
• Wash the pump after every use.

What if Hezkue doesn’t work the first time?

This is common. You may require:

• A higher or lower dose
• Using it on an empty stomach
• Ensuring adequate sexual stimulation
• Your clinician may adjust the dose (25–100 mg).

Who should NOT take Hezkue?

Do not use if you:

• Take nitrates or poppers (dangerous drop in blood pressure)
• Take Riociguat
• Have severe heart or liver problems
• Recently had a heart attack or stroke
• Have low blood pressure
• Have hereditary eye disorders such as retinitis pigmentosa
• Have ever had NAION (sudden vision loss)
• Are female or under 18

What medicines interact with Hezkue?

Important interactions include:

• Nitrates (contraindicated)
• Nitric oxide donors (poppers)
• Alpha-blockers (may cause dizziness; dose adjustment needed)
• Protease inhibitors (HIV treatment – start on lowest dose)
• Sacubitril/valsartan

What side effects should I expect?

Very common:

• Headache

Common:

• Nausea
• Flushing
• Indigestion
• Nasal congestion
• Vision colour changes
• Dizziness

Serious (rare – seek immediate help):

• Chest pain
• Sudden vision loss
• Erection lasting more than 4 hours (priapism)
• Severe skin reactions
• Sudden hearing loss

Does food or alcohol affect Hezkue?

• A heavy meal can delay onset.
• Excess alcohol reduces ability to get an erection.

Can I use Hezkue with other ED medications?

No. Do not combine with other oral or topical ED treatments.

How should I store Hezkue?

• No special storage requirements
• Use within 10 months after opening
• Keep out of sight and reach of children